Hmm I disagree. TNG's first 4 seasons did indeed follow a re-run friendly isolated storyline, But they also did something at the end of season 4 that paved the way for DS9, VOY and ENT to create reoccurring plotlines.
That thing has 5 words: "The Best of Both Worlds"
For those of you who don't know, this two part episode (Wolf 359/Locutus) laid the foundation for the rest of the series, It allowed further character development, and allowed the writing staff to freely make reference to past episodes:
A prime example of this took place in TNG "Lessons" when Picard spent a good 10 minutes making reference to his flute, which he got from The Kataan Probe in TNG "The Inner Light" when talking to LtCdr Daren.
Anyway its reasons like this (plus the fact that TNG was my first trek, introduced to me by my father) that I vote for TNG....plus the physics in it are pretty dope, and make a lot of sense to the geek that I am. (I was once a physics major, before switching to criminology/psychology).